Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier
نویسندگان
چکیده
منابع مشابه
Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier.
Diseases of the kidney filtration barrier are a leading cause of ESRD. Most disorders affect the podocytes, polarized cells with a limited capacity for self-renewal that require tightly controlled signaling to maintain their integrity, viability, and function. Here, we provide an atlas of in vivo phosphorylated, glomerulus-expressed proteins, including podocyte-specific gene products, identifie...
متن کاملProhibitin and mitochondrial biology.
Prohibitins are ubiquitous, evolutionarily conserved proteins that are mainly localized in mitochondria. The mitochondrial prohibitin complex comprises two subunits, PHB1 and PHB2. These two proteins assemble into a ring-like macromolecular structure at the inner mitochondrial membrane and are implicated in diverse cellular processes: from mitochondrial biogenesis and function to cell death and...
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The removal of unwanted or damaged mitochondria by autophagy, a process called mitophagy, is essential for key events in development, cellular homeostasis, tumor suppression, and prevention of neurodegeneration and aging. However, the precise mechanisms of mitophagy remain uncertain. Here, we identify the inner mitochondrial membrane protein, prohibitin 2 (PHB2), as a crucial mitophagy receptor...
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The mechanisms by which the kidney retains albumin and larger proteins in the circulation while excreting smaller solutes remain enigmatic despite intense investigation. Although the controversy largely plays out in academic journals, the problem is anything but academic, because the health of millions of adults hinges on effective treatment of proteinuric CKD. Proteinuria is associated with ca...
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Prohibitins (PHB1 and PHB2) are versatile proteins located at the inner mitochondrial membrane, maintaining normal mitochondrial function and morphology. They interact with the NADH dehydrogenase protein complex, which is essential for oxidoreductase activity within cells. However, their expression in lung epithelium, especially in smokers and patients with inflammatory lung diseases associated...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2016
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2015.12.018